ABSTRACT
Objective To evaluate the effects of electroacupuncture on clinical efficacy, changes of serum vascular endothelial growth factor (VEGF) and neuron specific enolase (NSE) in patients with acute cerebral infarction. Methods From January 2015 to June 2016, 96 patients with acute cerebral infarction were selected and randomly divided into control group (48 cases) and electroacupuncture group (48 cases). The control group was given routine treatment, and the electroacupuncture group was given acupuncture combined with scalp acupuncture and body acupuncture on the basis of routine treatment for two weeks. The clinical efficacy, NIHSS score, serum VEGF and NSE levels were evaluated in two groups of patients. Results After two weeks of treatment, the clinical effective rate was higher in electroacupuncture group than that of the control group (P<0.05). After one week and two weeks of treatment, the NIHSS score and serum NSE level were significantly decreased in both groups of patients compared with those before treatment (P<0.05). The NIHSS score and serum NSE level were lower in the electroacupuncture group than those in the control group (P<0.05). After one week and two weeks of treatment, serum VEGF levels were significantly increased compared with those before treatment in the two groups (P<0.05). The serum VEGF level was higher in electroacupuncture group than that in control group (P<0.05). Conclusion Electroacupuncture treatment can promote the regeneration of damaged blood vessels, repair neurons and improve clinical efficacy in patients with acute cerebral infarction, which shows definite clinical significance.
ABSTRACT
To analyze the prescription and medication rules of Chinese medicines in the treatment of palpitations in the Chinese journal full text database(CNKI) by using traditional Chinese medicine inheritance system, and provide a reference for further research and development of modern traditional Chinese medicines(TCMs) in treatment of palpitations. In order to give better guidance for clinical mediation, prescriptions used for treatment of palpitations in CNKI were collected, and then were input to the TCM inheritance support system for establishing a Chinese medicine prescription database for palpitations. The software's revised mutual information, complex system entropy clustering and other data mining methods were adopted to analyze the prescriptions according to the frequencies of herbs, "four natures", "five flavors" and "meridians" of the high-frequency medicines in the database, identify the core herbs and application characteristics, and analyze the prescription rules and medication experience. Totally, 545 prescriptions used for palpitation were included in this study and involved 247 Chinese herbs. The analysis results showed that the herbs in prescriptions for palpitation mostly had the warm property, and the herbs in heart and spleen meridian accounted for a larger proportion, indicating that the treatment was mainly to nourish heart and strengthen spleen. The top 11 herbs in usage frequency were consistent with the high-frequency medicines in medication patterns of common herbal pairs; therefore, we considered that these 11 herbs were the core herbs; the core herbal combination included Cassia Twig, Licorice, fossil fragments, Ostreae decoction, and evolved into 9 new prescriptions for treating palpitation. Our results objectively presented the prescription and medication rules for treating palpitation and provided extremely effective guidance for the clinical therapy.